The study of gene-environment interactions in psychiatry: Limited gains at a substantial cost?

S. Zammit*, N. Wiles, G. Lewis

*Corresponding author for this work

Research output: Contribution to journalEditorial (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

There is an ever-increasing body of literature examining gene-environment interactions in psychiatry, reflecting a widespread belief that such studies will aid identification of novel risk factors for disease, increase understanding about underlying pathological mechanisms, and aid identification of high-risk groups for targeted interventions. In this article we discuss to what extent studies of gene-environment interactions are likely to lead to any such benefits in the future.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalPsychological Medicine
Volume40
Issue number5
DOIs
Publication statusPublished - 1 Sept 2010

Keywords

  • Additive
  • Epidemiology
  • Gene-environment interactions
  • Genetics
  • Multiplicative

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