The SUPERFAMILY database in structural genomics

J. Gough

Research output: Contribution to journalArticle (Academic Journal)peer-review

28 Citations (Scopus)

Abstract

The SUPERFAMILY hidden Markov model library representing all proteins of known structure predicts the domain architecture of protein sequences and classifies them at the SCOP superfamily level. This analysis has been carried out on all completely sequenced genomes. The ways in which the database can be useful to crystallographers is discussed, in particular with a view to high-throughput structure determination. The application of the SUPERFAMILY database to different target-selection strategies is suggested: novel folds, novel domain combinations and targeted attacks on genomes. Use of the database for more general inquiry in the context of structural studies is also explained. The database provides evolutionary relationships between target proteins and other proteins of known structure through the SCOP database, genome assignments and multiple sequence alignments.
Translated title of the contributionThe SUPERFAMILY database in structural genomics
Original languageEnglish
Pages (from-to)1897-1900
Number of pages4
JournalActa Crystallographica Section D: Biological Crystallography
Volume58
Issue number11
Publication statusPublished - 2002

Bibliographical note

Other identifier: 1040020

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