The synthesis of (±)-epiquinamide 1 and (±)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [3H]epibatidine binding to rat brain membranes neither (±)-1 nor (±)-2 showed any significant level of nicotinic activity.
|Translated title of the contribution||The Synthesis and Nicotinic Binding Activity of (±)-Epiquinamide and (±)-C(1)-Epiepiquinamide|
|Pages (from-to)||4648 - 4651|
|Number of pages||4|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|Publication status||Published - Sep 2006|