The Synthesis and Nicotinic Binding Activity of (±)-Epiquinamide and (±)-C(1)-Epiepiquinamide

A Kanakubo, D Gray, N Innocent, S Wonnacott, T Gallagher

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

The synthesis of (±)-epiquinamide 1 and (±)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [3H]epibatidine binding to rat brain membranes neither (±)-1 nor (±)-2 showed any significant level of nicotinic activity.
Translated title of the contributionThe Synthesis and Nicotinic Binding Activity of (±)-Epiquinamide and (±)-C(1)-Epiepiquinamide
Original languageEnglish
Pages (from-to)4648 - 4651
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16 (17)
DOIs
Publication statusPublished - Sep 2006

Bibliographical note

Publisher: Elsevier

Fingerprint Dive into the research topics of 'The Synthesis and Nicotinic Binding Activity of (±)-Epiquinamide and (±)<i>-C(1)-Epie</i>piquinamide'. Together they form a unique fingerprint.

Cite this