The TeaM (Therapeutic Mammaplasty) Study: Protocol for a prospective multi-centre cohort study to evaluate the practice and outcomes of therapeutic mammaplasty

Elizabeth Baker, Baek Kim, Tim Rattay, Kathyrn Williams, Charlotte Ives, Dionysios-Dennis Remoundos, Matthew Gardiner, Abhi Jain, Richard Sutton, Raj Achuthan, Patricia fairbrother, Lisa Brock, Shweta Aggarwal, Naren Basu, John Murphy, Adam Trickey, R Douglas Macmillan, Shelley Potter

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)
581 Downloads (Pure)

Abstract

Introduction
Wide local excision and adjuvant radiotherapy is the standard of care for early breast cancer. For large tumours, however, mastectomy is frequently recommended as conventional breast-conserving techniques often result in poor cosmetic outcomes. Therapeutic mammaplasty (TM) may extend the boundaries of breast-conserving surgery by combining breast reduction and mastopexy techniques with tumour excision, preserving a natural breast shape and avoiding the need for mastectomy. The prevalence of this operative option among surgeons in the UK and its success rate are unknown. The TeaM study is a multicentre prospective study that aims to investigate the practice and outcomes of TM.

Methods and Analysis
Breast centres performing TM will be invited to participate through the research collaborative network and the professional associations. All patients undergoing TM between September 2016 and March 2017 will be included. Demographic, operative, oncological and complication data within 30-days of surgery will be collected. The primary outcome will be unplanned re-operation for complications. Secondary outcomes will include unplanned readmission, re-excision rates and time to adjuvant therapy. Prospective data on 500 patients from 50 centres is anticipated. Exploratory analyses will identify predictors for complications and inform the design of a definitive study.

Ethics and dissemination
Research ethics approval is not required for this study. This has been confirmed by the on-line Health Research Authority decision tool. This study will provide novel information regarding the practice and outcomes of TM in the UK. This will inform decision-making for patients and surgeons and inform future research. Dissemination of the study protocol will be via the Mammary Fold Academic and Research Collaborative, the Reconstructive Surgery Trials Network and the professional associations, the Association of Breast Surgery and British Association of Plastic, Reconstructive and Aesthetic Surgeons. Results will be presented at relevant surgical conferences and published in peer-reviewed journals.
Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalInternational Journal of Surgery Protocols
Volume1
Early online date19 Oct 2016
DOIs
Publication statusPublished - Oct 2016

Structured keywords

  • Centre for Surgical Research

Keywords

  • therapeutic mammaplasty
  • trainee collaboratives
  • COMPLICATIONS
  • Cohort study
  • adjuvant therapy

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