The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies

N M G De Silva, A Steele, B Shields, B Knight, K Parnell, M N Weedon, A T Hattersley, T M Frayling

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)

Abstract

Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies.
Original languageEnglish
Pages (from-to)1067-72
Number of pages6
JournalDiabetic Medicine
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Adult
  • Alleles
  • Diabetes Mellitus, Type 2
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • TCF Transcription Factors
  • Transcription Factor 7-Like 2 Protein

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