The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies

N M G De Silva; A Steele; B Shields; B Knight; K Parnell; M N Weedon; A T Hattersley; T M Frayling

doi:10.1111/j.1464-5491.2007.02253.x

The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies

N M G De Silva, A Steele, B Shields, B Knight, K Parnell, M N Weedon, A T Hattersley, T M Frayling

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

18 Citations (Scopus)

Abstract

Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies.

Original language	English
Pages (from-to)	1067-72
Number of pages	6
Journal	Diabetic Medicine
Volume	24
Issue number	10
DOIs	https://doi.org/10.1111/j.1464-5491.2007.02253.x
Publication status	Published - Oct 2007

Keywords

Adult
Alleles
Diabetes Mellitus, Type 2
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
TCF Transcription Factors
Transcription Factor 7-Like 2 Protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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De Silva, N. M. G., Steele, A., Shields, B., Knight, B., Parnell, K., Weedon, M. N., Hattersley, A. T., & Frayling, T. M. (2007). The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies. Diabetic Medicine, 24(10), 1067-72. https://doi.org/10.1111/j.1464-5491.2007.02253.x

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title = "The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies",

abstract = "Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies.",

keywords = "Adult, Alleles, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein",

author = "{De Silva}, {N M G} and A Steele and B Shields and B Knight and K Parnell and Weedon, {M N} and Hattersley, {A T} and Frayling, {T M}",

year = "2007",

month = oct,

doi = "10.1111/j.1464-5491.2007.02253.x",

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volume = "24",

pages = "1067--72",

journal = "Diabetic Medicine",

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De Silva, NMG, Steele, A, Shields, B, Knight, B, Parnell, K, Weedon, MN, Hattersley, AT & Frayling, TM 2007, 'The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies', Diabetic Medicine, vol. 24, no. 10, pp. 1067-72. https://doi.org/10.1111/j.1464-5491.2007.02253.x

The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies. / De Silva, N M G; Steele, A; Shields, B et al.
In: Diabetic Medicine, Vol. 24, No. 10, 10.2007, p. 1067-72.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Shields, B

AU - Knight, B

AU - Parnell, K

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AU - Hattersley, A T

AU - Frayling, T M

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N2 - Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies.

AB - Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies.

KW - Adult

KW - Alleles

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - TCF Transcription Factors

KW - Transcription Factor 7-Like 2 Protein

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