The twisted amide 2-quinuclidone: 60 Years in the making

Jonathan Clayden*, Wesley J. Moran

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

63 Citations (Scopus)


(Chemical Equation Presented) No longer left to the imagination: Non-planar amides have intrigued chemists for decades. This year, a story 60 years in the making came to an end: 2-quinuclidone has finally been synthesized and isolated in the form of its HBF4 salt (see scheme).

Original languageEnglish
Pages (from-to)7118-7120
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number43
Early online date29 Sep 2006
Publication statusPublished - 6 Nov 2006


  • Amides
  • Penicillin
  • Reactivity
  • Strained molecules
  • Synthetic methods

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