The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study

Sarah J Kitson, Jennifer Lindsay, Vanitha N Sivalingam, Mark Lunt, Neil A J Ryan, Richard J Edmondson, Martin K Rutter, Emma J Crosbie

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

BACKGROUND: Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population.

METHODS: The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014.

RESULTS: Women with endometrial cancer had higher proportions of obesity (BMI≥30 60.7% vs. 32.4%, p<0.0001) and a preponderance of unrecognized and inadequately treated cardiovascular risk factors. Compared with controls, endometrial cancer cases had a higher prevalence of incident hyperglycemia (57.2%vs.11.5%, p<0.0001), total: HDL cholesterol ratio>4.5 (26.7%vs.13.7%, p<0.0001), and were more likely to have three or more cardiovascular risk factors (22%vs.6%, p<0.0001). This equates to a higher 10-year cardiovascular risk (median QRISK2 score 12.6% vs. 8.8%, p<0.0001). Optimization of risk factors would have a greater impact on absolute cardiovascular disease risk for cases than controls (QRISK2 score reduction 1.8% vs. 0.7%).

CONCLUSIONS: Women undergoing primary treatment for endometrial cancer have a higher prevalence of cardiovascular risk factors than women without the disease. Early identification and treatment of these risk factors could improve outcomes for endometrial cancer survivors.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalGynecologic Oncology
Volume148
Issue number1
DOIs
Publication statusPublished - Jan 2018

Bibliographical note

Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords

  • Adult
  • Cardiovascular Diseases/epidemiology
  • Case-Control Studies
  • Endometrial Neoplasms/diagnosis
  • England/epidemiology
  • Female
  • Humans
  • Prospective Studies
  • Risk Factors

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