Abstract
A genetically engineered version of Bacillus stearothermophilus lactate dehydrogenase, incorporating structural motifs which serve to alter substrate specificity in favour of alpha-keto acids with bulky aliphatic side chains, was used to effect enantioselective reduction of 4-methyl-2-oxopent-3-enoic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 924-926 |
| Number of pages | 3 |
| Journal | Journal of the Chemical Society: Chemical Communications |
| Volume | 30 |
| Issue number | 13 |
| Publication status | Published - 1 Jul 1992 |