Bibliographical noteFunding Information:
Conflicts of interests: P.T. has consulted for Astra-Zeneca and Duke-NUS. J.H. reports the Clinical Trial Service Unit receives research grants from the pharmaceutical industry. In addition to University of Oxford affilitation, J.H-C. is founder and director of QResearch database, co-owner of ClinRisk Ltd, and was a paid director there until June 2019. No other authors have any competing interests to declare. The authors declare that no support from any organization and no financial relationships have influenced the submitted work.
S.J.G. is supported by an MRC Epidemiology Unit program: MC_UU_12015/4. The University of Cambridge has received salary support for S.J.G. from the NHS in the East of England through the Clinical Academic Reserve. H.D-M. is a NIHR funded Academic Clinical Lecturer. R.M.M. is supported in part by the NIHR Bristol Bio-medical Research Centre and by a Cancer Research UK (C18281/A19169) program grant (the Integrative Cancer Epidemiology Programme). P.W. is supported in part by the NIHR Oxford Biomedical Research Centre. J.C.H. acknowledges personal support from the British Heart Foundation (FS/14/55/30806) and Cancer Research UK (C5255/A18085) through the Cancer Research UK Oxford Centre. J.H-C. also receives support from the NHS and NIHR. J.M. is an NIHR Senior Investigator.
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