The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

C Pena Murillo; X Huang; A Hills; M McGurk; A Lyons; J-P Jeannon; E Odell; A Brown; K Lavery; W Barrett; M Sherriff; R Brakenhoff; M Partridge

doi:10.1038/bjc.2012.213

The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

C Pena Murillo, X Huang, A Hills, M McGurk, A Lyons, J-P Jeannon, E Odell, A Brown, K Lavery, W Barrett, M Sherriff, R Brakenhoff, M Partridge

Bristol Dental School

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.

Original language	English
Pages (from-to)	1138-43
Number of pages	6
Journal	British Journal of Cancer
Volume	107
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2012.213
Publication status	Published - 25 Sep 2012

Keywords

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Female
Genes, p53
Head and Neck Neoplasms
Humans
Male
Middle Aged
Mutation
Neoplasm Recurrence, Local
Pathology, Molecular
Prospective Studies
Tumor Markers, Biological

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10.1038/bjc.2012.213

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title = "The utility of molecular diagnostics to predict recurrence of head and neck carcinoma",

abstract = "Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.",

keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Female, Genes, p53, Head and Neck Neoplasms, Humans, Male, Middle Aged, Mutation, Neoplasm Recurrence, Local, Pathology, Molecular, Prospective Studies, Tumor Markers, Biological",

author = "{Pena Murillo}, C and X Huang and A Hills and M McGurk and A Lyons and J-P Jeannon and E Odell and A Brown and K Lavery and W Barrett and M Sherriff and R Brakenhoff and M Partridge",

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journal = "British Journal of Cancer",

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The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. / Pena Murillo, C; Huang, X; Hills, A; McGurk, M; Lyons, A; Jeannon, J-P; Odell, E; Brown, A; Lavery, K; Barrett, W; Sherriff, M; Brakenhoff, R; Partridge, M.

In: British Journal of Cancer, Vol. 107, No. 7, 25.09.2012, p. 1138-43.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

AU - Pena Murillo, C

AU - Huang, X

AU - Hills, A

AU - McGurk, M

AU - Lyons, A

AU - Jeannon, J-P

AU - Odell, E

AU - Brown, A

AU - Lavery, K

AU - Barrett, W

AU - Sherriff, M

AU - Brakenhoff, R

AU - Partridge, M

PY - 2012/9/25

Y1 - 2012/9/25

N2 - Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.

AB - Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Squamous Cell

KW - Female

KW - Genes, p53

KW - Head and Neck Neoplasms

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Neoplasm Recurrence, Local

KW - Pathology, Molecular

KW - Prospective Studies

KW - Tumor Markers, Biological

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DO - 10.1038/bjc.2012.213

M3 - Article (Academic Journal)

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VL - 107

SP - 1138

EP - 1143

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 7

ER -