The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

C Pena Murillo, X Huang, A Hills, M McGurk, A Lyons, J-P Jeannon, E Odell, A Brown, K Lavery, W Barrett, M Sherriff, R Brakenhoff, M Partridge

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.
Original languageEnglish
Pages (from-to)1138-43
Number of pages6
JournalBritish Journal of Cancer
Volume107
Issue number7
DOIs
Publication statusPublished - 25 Sep 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell
  • Female
  • Genes, p53
  • Head and Neck Neoplasms
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Neoplasm Recurrence, Local
  • Pathology, Molecular
  • Prospective Studies
  • Tumor Markers, Biological

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