Abstract
Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.
Original language | English |
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Pages (from-to) | 1138-43 |
Number of pages | 6 |
Journal | British Journal of Cancer |
Volume | 107 |
Issue number | 7 |
DOIs | |
Publication status | Published - 25 Sep 2012 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Recurrence, Local
- Pathology, Molecular
- Prospective Studies
- Tumor Markers, Biological