The vascular impairment of cognition classification consensus study

Olivia A. Skrobot, John O'Brien, Sandra Black, Christopher Chen, Charles DeCarli, Timo Erkinjuntti, Gary A. Ford, Rajesh N. Kalaria, Leonardo Pantoni, Florence Pasquier, Gustavo C. Roman, Anders Wallin, Perminder Sachdev, Ingmar Skoog, Yoav Ben-Shlomo, Anthony P. Passmore, Seth Love, Patrick G. Kehoe*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

129 Citations (Scopus)
511 Downloads (Pure)


Introduction: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment. Methods: The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines. Results: VICCCS had a mean of 122 (98-153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge. Discussion: VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research.

Original languageEnglish
Number of pages10
JournalAlzheimer's and Dementia
Early online date10 Dec 2016
Publication statusE-pub ahead of print - 10 Dec 2016


  • Consensus
  • Criteria
  • Delphi
  • Guidelines
  • Vascular cognitive impairment
  • Vascular dementia


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