The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

Katherine Parker; A. Mesut Erzurumluoglu; Santiago Rodriguez

doi:10.3390/genes11111273

The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

Katherine Parker
, A. Mesut Erzurumluoglu
, Santiago Rodriguez^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

18 Citations (Scopus)

364 Downloads (Pure)

Abstract

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY

Original language	English
Article number	1273
Number of pages	19
Journal	Genes
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/genes11111273
Publication status	Published - 29 Oct 2020

Keywords

Y chromosome
Y haplogroups
complex locus
genetic association analyses
genetic epidemiology
complex human traits

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10.3390/genes11111273

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This is the final published version of the article (version of record). It first appeared online via MDPI at https://doi.org/10.3390/genes11111273. Please refer to any applicable terms of use of the publisher.
Final published version, 1.2 MBLicence: CC BY

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IEU 2 Relton Programme - Epigenetic Epidemiology
Relton, C. L. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

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title = "The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits",

abstract = "The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY",

keywords = "Y chromosome, Y haplogroups, complex locus, genetic association analyses, genetic epidemiology, complex human traits",

author = "Katherine Parker and Erzurumluoglu, \{A. Mesut\} and Santiago Rodriguez",

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T2 - A Complex Locus for Genetic Analyses of Complex Human Traits

AU - Parker, Katherine

AU - Erzurumluoglu, A. Mesut

AU - Rodriguez, Santiago

PY - 2020/10/29

Y1 - 2020/10/29

N2 - The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY

AB - The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY

KW - Y chromosome

KW - Y haplogroups

KW - complex locus

KW - genetic association analyses

KW - genetic epidemiology

KW - complex human traits

U2 - 10.3390/genes11111273

DO - 10.3390/genes11111273

M3 - Review article (Academic Journal)

C2 - 33137877

SN - 2073-4425

VL - 11

JO - Genes

JF - Genes

IS - 11

M1 - 1273

ER -

The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

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Keywords

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IEU 2 Relton Programme - Epigenetic Epidemiology

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