Thirty years of neuroendocrinology: technological advances pave the way for molecular discovery

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Abstract

Since the 1950s, the systems level interactions between the hypothalamus, pituitary and end organs such as the adrenal, thyroid and gonads have been well known; however, it is only over the last three decades that advances in molecular biology and information technology have provided a tremendous expansion of knowledge at the molecular level. Neuroendocrinology has benefitted from developments in molecular genetics, epigenetics and epigenomics, and most recently optogenetics and pharmacogenetics. This has enabled a new understanding of gene regulation, transcription, translation and post-translational regulation, which should help direct the development of drugs to treat neuroendocrine-related diseases.
Original languageEnglish
Article numbere12653
Number of pages10
JournalJournal of Neuroendocrinology
Volume31
Issue number3
Early online date29 Nov 2018
DOIs
Publication statusPublished - 22 Mar 2019

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