Three-Dimensional Printing of Fetal Models of Congenital Heart Disease Derived From Microfocus Computed Tomography:  A Case Series

Camilla Sandrini; Claudio Lombardi; Andrew I U Shearn; Victoria V Ordonez; Massimo Caputo; Francesca Presti; Giovanni Battista Luciani; Lucia Rossetti; Giovanni Biglino

doi:10.3389/fped.2019.00567

Three-Dimensional Printing of Fetal Models of Congenital Heart Disease Derived From Microfocus Computed Tomography: A Case Series

Camilla Sandrini^*, Claudio Lombardi, Andrew I U Shearn, Victoria V Ordonez, Massimo Caputo, Francesca Presti, Giovanni Battista Luciani, Lucia Rossetti, Giovanni Biglino

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

164 Downloads (Pure)

Abstract

This article presents a case series of n = 21 models of fetal cardiovascular anatomies obtained from post mortem microfocus computed tomography (micro-CT) data. The case series includes a broad range of diagnoses (e.g., tetralogy of Fallot, hypoplastic left heart syndrome, dextrocardia, double outlet right ventricle, atrio-ventricular septal defect) and cases also had a range of associated extra-cardiac malformations (e.g., VACTERL syndrome, central nervous system anomalies, renal anomalies). All cases were successfully reconstructed from the microfocus computed tomography data, demonstrating the feasibility of the technique and of the protocols, including in-house printing with a desktop 3D printer (Form2, Formlabs). All models were printed in 1:1 scale as well as with the 5-fold magnification, to provide insight into the intra-cardiac structures. Possible uses of the models include education and training.

Original language	English
Article number	567
Number of pages	6
Journal	Frontiers in Pediatrics
Volume	7
DOIs	https://doi.org/10.3389/fped.2019.00567
Publication status	Published - 21 Jan 2020

Research Groups and Themes

Bristol Heart Institute

Keywords

3D printing
microfocus computed tomography
fetal heart
congenital heart disease`
fetal cardiology
prenatal diagnosis

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10.3389/fped.2019.00567

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title = "Three-Dimensional Printing of Fetal Models of Congenital Heart Disease Derived From Microfocus Computed Tomography: A Case Series",

abstract = "This article presents a case series of n = 21 models of fetal cardiovascular anatomies obtained from post mortem microfocus computed tomography (micro-CT) data. The case series includes a broad range of diagnoses (e.g., tetralogy of Fallot, hypoplastic left heart syndrome, dextrocardia, double outlet right ventricle, atrio-ventricular septal defect) and cases also had a range of associated extra-cardiac malformations (e.g., VACTERL syndrome, central nervous system anomalies, renal anomalies). All cases were successfully reconstructed from the microfocus computed tomography data, demonstrating the feasibility of the technique and of the protocols, including in-house printing with a desktop 3D printer (Form2, Formlabs). All models were printed in 1:1 scale as well as with the 5-fold magnification, to provide insight into the intra-cardiac structures. Possible uses of the models include education and training.",

keywords = "3D printing, microfocus computed tomography, fetal heart, congenital heart disease`, fetal cardiology, prenatal diagnosis",

author = "Camilla Sandrini and Claudio Lombardi and Shearn, {Andrew I U} and Ordonez, {Victoria V} and Massimo Caputo and Francesca Presti and {Battista Luciani}, Giovanni and Lucia Rossetti and Giovanni Biglino",

year = "2020",

month = jan,

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doi = "10.3389/fped.2019.00567",

language = "English",

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T1 - Three-Dimensional Printing of Fetal Models of Congenital Heart Disease Derived From Microfocus Computed Tomography

T2 - A Case Series

AU - Sandrini, Camilla

AU - Lombardi, Claudio

AU - Shearn, Andrew I U

AU - Ordonez, Victoria V

AU - Caputo, Massimo

AU - Presti, Francesca

AU - Battista Luciani, Giovanni

AU - Rossetti, Lucia

AU - Biglino, Giovanni

PY - 2020/1/21

Y1 - 2020/1/21

N2 - This article presents a case series of n = 21 models of fetal cardiovascular anatomies obtained from post mortem microfocus computed tomography (micro-CT) data. The case series includes a broad range of diagnoses (e.g., tetralogy of Fallot, hypoplastic left heart syndrome, dextrocardia, double outlet right ventricle, atrio-ventricular septal defect) and cases also had a range of associated extra-cardiac malformations (e.g., VACTERL syndrome, central nervous system anomalies, renal anomalies). All cases were successfully reconstructed from the microfocus computed tomography data, demonstrating the feasibility of the technique and of the protocols, including in-house printing with a desktop 3D printer (Form2, Formlabs). All models were printed in 1:1 scale as well as with the 5-fold magnification, to provide insight into the intra-cardiac structures. Possible uses of the models include education and training.

AB - This article presents a case series of n = 21 models of fetal cardiovascular anatomies obtained from post mortem microfocus computed tomography (micro-CT) data. The case series includes a broad range of diagnoses (e.g., tetralogy of Fallot, hypoplastic left heart syndrome, dextrocardia, double outlet right ventricle, atrio-ventricular septal defect) and cases also had a range of associated extra-cardiac malformations (e.g., VACTERL syndrome, central nervous system anomalies, renal anomalies). All cases were successfully reconstructed from the microfocus computed tomography data, demonstrating the feasibility of the technique and of the protocols, including in-house printing with a desktop 3D printer (Form2, Formlabs). All models were printed in 1:1 scale as well as with the 5-fold magnification, to provide insight into the intra-cardiac structures. Possible uses of the models include education and training.

KW - 3D printing

KW - microfocus computed tomography

KW - fetal heart

KW - congenital heart disease`

KW - fetal cardiology

KW - prenatal diagnosis

U2 - 10.3389/fped.2019.00567

DO - 10.3389/fped.2019.00567

M3 - Article (Academic Journal)

C2 - 32039123

SN - 2296-2360

VL - 7

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

M1 - 567

ER -