Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Stephen A Hill, David Benito-Alifonso, Sean A Davis, Monica Berry, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)
312 Downloads (Pure)

Abstract

A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.
Original languageEnglish
Pages (from-to)18630-18634
Number of pages5
JournalNanoscale
Volume8
Issue number44
Early online date21 Oct 2016
DOIs
Publication statusPublished - 10 Nov 2016

Structured keywords

  • BCS and TECS CDTs

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