Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Stephen A Hill; David Benito-Alifonso; Sean A Davis; Monica Berry; M Carmen Galan

doi:10.1039/c6nr07336k

Three-minute synthesis of sp³ nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Stephen A Hill, David Benito-Alifonso, Sean A Davis, Monica Berry, M Carmen Galan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

A one-pot, three-minute, gram-scale synthesis of novel sp³-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH₂-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

Original language	English
Pages (from-to)	18630-18634
Number of pages	5
Journal	Nanoscale
Volume	8
Issue number	44
Early online date	21 Oct 2016
DOIs	https://doi.org/10.1039/c6nr07336k
Publication status	Published - 10 Nov 2016

Research Groups and Themes

BCS and TECS CDTs

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10.1039/c6nr07336k

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This is the final published version of the article (version of record). It first appeared online via Royal Society of Chemistry at DOI: 10.1039/C6NR07336K. Please refer to any applicable terms of use of the publisher.
Final published version, 1.01 MBLicence: CC BY

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Catalytic stereoselective synthesis of glycosides
Galan, M. C. (Principal Investigator)
1/07/13 → 1/07/15
Project: Research
3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
Reworking of Novel tools for Glycoscience
Galan, M. C. (Principal Investigator)
31/03/12 → 30/08/17
Project: Research

Wolfson Bioimaging Facility
Jepson, M. (Manager)
Faculty of Life Sciences
Facility/equipment: Facility

Professor M C Galan
- M.C.Galanbristol.acuk
- School of Chemistry - Professor of Organic and Biological Chemistry
Person: Academic

Cite this

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title = "Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery",

abstract = "A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.",

author = "Hill, {Stephen A} and David Benito-Alifonso and Davis, {Sean A} and Monica Berry and Galan, {M Carmen}",

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doi = "10.1039/c6nr07336k",

language = "English",

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journal = "Nanoscale",

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AU - Hill, Stephen A

AU - Benito-Alifonso, David

AU - Davis, Sean A

AU - Berry, Monica

AU - Galan, M Carmen

PY - 2016/11/10

Y1 - 2016/11/10

N2 - A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

AB - A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

U2 - 10.1039/c6nr07336k

DO - 10.1039/c6nr07336k

M3 - Article (Academic Journal)

C2 - 27801469

SN - 2040-3364

VL - 8

SP - 18630

EP - 18634

JO - Nanoscale

JF - Nanoscale

IS - 44

ER -

Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Abstract

Research Groups and Themes

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Projects

Catalytic stereoselective synthesis of glycosides

3-month Core Capability for Chemistry Research

Reworking of Novel tools for Glycoscience

Equipment

Wolfson Bioimaging Facility

Profiles

Professor M C Galan

Cite this

Three-minute synthesis of sp³ nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery