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Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)18630-18634
Number of pages5
Issue number44
Early online date21 Oct 2016
DateSubmitted - 16 Sep 2016
DateAccepted/In press - 20 Oct 2016
DateE-pub ahead of print - 21 Oct 2016
DatePublished (current) - 10 Nov 2016


A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Royal Society of Chemistry at DOI: 10.1039/C6NR07336K. Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY


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