Thrombospondin-1 Polymorphisms Influence Risk of Corneal Allograft Rejection

Helen L Winton, W J Armitage, Jeffrey L Bidwell

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Abstract

PURPOSE. We investigated single nucleotide polymorphisms (SNPs) of thrombospondin-1 (TSP-1) on the risk of corneal allograft rejection. The TSP-1 is known to be involved in the immune response of the anterior chamber of the eye, activating TGF-b2, promoting peripheral and systemic tolerance, and counteracting the proangiogenic activity of VEGF.
METHODS. Three tagging SNPs spanning the TSP-1 region (rs1478604, A>G; rs2228261, C>T; and rs2228262, A>G) were genotyped. Association with risk of rejection was investigated in a group of 378 corneal transplant recipients with risk factors for allograft rejection. Transplant recipients had completed 3-year follow-up.
RESULTS. The TSP-1 rs1478604 A SNP was associated significantly with an increased risk of corneal allograft rejection (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.02–2.45; P= 0.04) and there was a trend toward the rs1478604, rs2228261, rs2228262 ACA haplotypeincreasing risk of rejection.
CONCLUSIONS. The results suggest that TSP-1 rs1478604 AA homozygotes may be at increased risk of corneal transplant rejection, especially if they carry the ACA haplotype.
Keywords: corneal transplantation, thrombospondin-1, single nucleotide polymorphism
Original languageEnglish
Article numberDOI: 10.1167/iovs.13-13681
Pages (from-to)2115-2120
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number4
DOIs
Publication statusPublished - 7 Apr 2014

Keywords

  • corneal transplantation
  • thrombospondin-1
  • Single nucleotide polymorphism

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