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Thyroid and renal function in cats following low-dose radioiodine (111Mbq) therapy

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)523-528
Number of pages6
JournalJournal of Small Animal Practice
Volume60
Issue number9
Early online date22 Jul 2019
DOIs
DateAccepted/In press - 17 Jun 2019
DateE-pub ahead of print - 22 Jul 2019
DatePublished (current) - 5 Sep 2019

Abstract

Objectives: To describe the effect of low-dose (111MBq) radioiodine therapy (RAI) on thyroid and renal function in hyperthyroid cats over a 12 month follow-up period.

Materials and Methods: Client-owned hyperthyroid cats underwent treatment with low-dose RAI and were followed for 12 months post-RAI treatment. Immediately prior to RAI treatment, and subsequently at one, six and 12 months post-RAI treatment, thyroid function was evaluated using total thyroxine (TT4) and thyroid stimulating hormone (TSH) and renal function was evaluated using serum creatinine concentration and glomerular filtration rate (GFR).

Results: Fifteen of the 24 (63%) cats achieved euthyroidism following low-dose RAI treatment. The incidence of development of overt hypothyroidism was 25% (6/24 cats). Of the cats developing overt hypothyroidism, 3/6 (50%) had decreased renal function, with decreased GFR preceding development of azotaemia in 2 out of 3 of these cats. Transient overt or subclinical hypothyroidism prior to restoration of euthyroidism was not observed in any cats.

Clinical Significance: Low-dose RAI is effective for most cats with hyperthyroidism, however, overt hypothyroidism may develop in some. Concurrent early decline in renal function may only be detected by measuring GFR rather than serum creatinine in some patients. Monitoring of patients post-RAI treatment should include TT4 and TSH with consideration of GFR measurement in non-azotaemic cats.

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1111/jsap.13057 . Please refer to any applicable terms of use of the publisher.

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    Embargo ends: 22/07/20

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