Time-delayed models of gene regulatory networks

K. Parmar, K. B. Blyuss*, Y. N. Kyrychko, S. J. Hogan

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.

Original languageEnglish
Article number347273
JournalComputational and Mathematical Methods in Medicine
Volume2015
DOIs
Publication statusPublished - 1 Jan 2015

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