Time to reconsider the role of ribavirin in Lassa fever

Alex Paddy Salam; Hung-Yuan Cheng; Tansy  Edwards; Piero Olliaro; Jonathan Sterne; Peter Horby

doi:10.1371/journal.pntd.0009522

Time to reconsider the role of ribavirin in Lassa fever

Alex Paddy Salam^*, Hung-Yuan Cheng^*, Tansy Edwards, Piero Olliaro, Jonathan Sterne, Peter Horby

^*Corresponding author for this work

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Abstract

Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some Lassa fever patients. An urgent reevaluation of ribavirin is therefore needed.

Original language	English
Article number	e0009522
Pages (from-to)	e0009522
Number of pages	5
Journal	PLoS Neglected Tropical Diseases
Volume	15
Issue number	7
DOIs	https://doi.org/10.1371/journal.pntd.0009522
Publication status	Published - 8 Jul 2021

Bibliographical note

Funding Information:
APS is funded by UK aid from the Department of Health and Social Care via the UK Public Health Rapid Support Team Research Programme. The funder had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.

Publisher Copyright:
© 2021 Salam et al.

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AU - Horby, Peter

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Time to reconsider the role of ribavirin in Lassa fever

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