Timing the ischaemic stroke by H-1-MRI: improved accuracy using absolute relaxation times over signal intensities

Harriet J. Rogers, Bryony L. McGarry, Michael J. Knight, Kimmo T. Jokivarsi, Olli H. J. Grohn, Risto A. Kauppinen*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

One in four ischaemic stroke patients are ineligible for thrombolytic treatment due to unknown onset time. Quantification of absolute MR relaxation times and signal intensities are potential methods for estimating stroke duration. We compared the accuracy of these approaches and determined whether changes in relaxation times and signal intensities identify the same ischaemic tissue as diffusion MRI. Seven Wistar rats underwent permanent middle cerebral artery occlusion to induce focal ischaemia and were scanned at six time points. The trace of the diffusion tensor (D-AV), T-1 and T-2 were acquired at 4.7T. Results show relaxation times, and signal intensities of the MR relaxation parameters increase linearly with ischaemia duration (P

Original languageEnglish
Pages (from-to)1180-1185
Number of pages6
JournalNeuroReport
Volume25
Issue number15
DOIs
Publication statusPublished - 22 Oct 2014

Structured keywords

  • CRICBristol
  • Brain and Behaviour
  • Cognitive Science

Keywords

  • irreversible ischaemia
  • ischaemic stroke
  • magnetic resonance imaging
  • onset time
  • relaxation times
  • signal intensities
  • T-2
  • T-1
  • FOCAL CEREBRAL-ISCHEMIA
  • APPARENT DIFFUSION-COEFFICIENT
  • SYMPTOM ONSET
  • WATER POOLS
  • RAT
  • EVOLUTION
  • MRI
  • T-1-RHO
  • BRAIN
  • FLAIR

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