Abstract
One in four ischaemic stroke patients are ineligible for thrombolytic treatment due to unknown onset time. Quantification of absolute MR relaxation times and signal intensities are potential methods for estimating stroke duration. We compared the accuracy of these approaches and determined whether changes in relaxation times and signal intensities identify the same ischaemic tissue as diffusion MRI. Seven Wistar rats underwent permanent middle cerebral artery occlusion to induce focal ischaemia and were scanned at six time points. The trace of the diffusion tensor (D-AV), T-1 and T-2 were acquired at 4.7T. Results show relaxation times, and signal intensities of the MR relaxation parameters increase linearly with ischaemia duration (P
| Original language | English |
|---|---|
| Pages (from-to) | 1180-1185 |
| Number of pages | 6 |
| Journal | NeuroReport |
| Volume | 25 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 22 Oct 2014 |
Research Groups and Themes
- CRICBristol
- Brain and Behaviour
- Cognitive Science
Keywords
- irreversible ischaemia
- ischaemic stroke
- magnetic resonance imaging
- onset time
- relaxation times
- signal intensities
- T-2
- T-1
- FOCAL CEREBRAL-ISCHEMIA
- APPARENT DIFFUSION-COEFFICIENT
- SYMPTOM ONSET
- WATER POOLS
- RAT
- EVOLUTION
- MRI
- T-1-RHO
- BRAIN
- FLAIR
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Clinical Research and Imaging Centre (CRICBristol)
Thai, J. (Manager), Bucciarelli-Ducci, C. (Other) & Gilchrist, I. (Other)
Bristol Medical School (THS)Facility/equipment: Facility