Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases

Ian Cummings; Sarah George; Jens Kelm; Doerthe Schmidt; Maximilian Y Emmert; Benedikt Weber; Gregor Zünd; Simon P Hoerstrup

doi:10.1016/j.ejcts.2011.02.077

Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases

Ian Cummings, Sarah George, Jens Kelm, Doerthe Schmidt, Maximilian Y Emmert, Benedikt Weber, Gregor Zünd, Simon P Hoerstrup

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Abstract

We have previously demonstrated the functionality and growth of autologous, living, tissue-engineered vascular grafts (TEVGs) in long-term animal studies. These grafts showed substantial in vivo tissue remodeling and approximation to native arterial wall characteristics. Based on this, in vitro and in vivo matrix metalloproteinase (MMP) activity of TEVGs is investigated as a key marker of matrix remodeling.

Original language	English
Pages (from-to)	167-72
Number of pages	6
Journal	European Journal of Cardio-Thoracic Surgery
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ejcts.2011.02.077
Publication status	Published - Jan 2012

Keywords

Animals
Tissue Engineering
Matrix Metalloproteinase 2
Sheep
Tissue Culture Techniques
Tissue Scaffolds
Disease Models, Animal
Collagen
Pulmonary Artery
Matrix Metalloproteinases
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Absorbable Implants
Biological Markers
Matrix Metalloproteinase 9

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title = "Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases",

abstract = "We have previously demonstrated the functionality and growth of autologous, living, tissue-engineered vascular grafts (TEVGs) in long-term animal studies. These grafts showed substantial in vivo tissue remodeling and approximation to native arterial wall characteristics. Based on this, in vitro and in vivo matrix metalloproteinase (MMP) activity of TEVGs is investigated as a key marker of matrix remodeling.",

keywords = "Animals, Tissue Engineering, Matrix Metalloproteinase 2, Sheep, Tissue Culture Techniques, Tissue Scaffolds, Disease Models, Animal, Collagen, Pulmonary Artery, Matrix Metalloproteinases, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Absorbable Implants, Biological Markers, Matrix Metalloproteinase 9",

author = "Ian Cummings and Sarah George and Jens Kelm and Doerthe Schmidt and Emmert, {Maximilian Y} and Benedikt Weber and Gregor Z{\"u}nd and Hoerstrup, {Simon P}",

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T1 - Tissue-engineered vascular graft remodeling in a growing lamb model

T2 - expression of matrix metalloproteinases

AU - Cummings, Ian

AU - George, Sarah

AU - Kelm, Jens

AU - Schmidt, Doerthe

AU - Emmert, Maximilian Y

AU - Weber, Benedikt

AU - Zünd, Gregor

AU - Hoerstrup, Simon P

PY - 2012/1

Y1 - 2012/1

N2 - We have previously demonstrated the functionality and growth of autologous, living, tissue-engineered vascular grafts (TEVGs) in long-term animal studies. These grafts showed substantial in vivo tissue remodeling and approximation to native arterial wall characteristics. Based on this, in vitro and in vivo matrix metalloproteinase (MMP) activity of TEVGs is investigated as a key marker of matrix remodeling.

AB - We have previously demonstrated the functionality and growth of autologous, living, tissue-engineered vascular grafts (TEVGs) in long-term animal studies. These grafts showed substantial in vivo tissue remodeling and approximation to native arterial wall characteristics. Based on this, in vitro and in vivo matrix metalloproteinase (MMP) activity of TEVGs is investigated as a key marker of matrix remodeling.

KW - Animals

KW - Tissue Engineering

KW - Matrix Metalloproteinase 2

KW - Sheep

KW - Tissue Culture Techniques

KW - Tissue Scaffolds

KW - Disease Models, Animal

KW - Collagen

KW - Pulmonary Artery

KW - Matrix Metalloproteinases

KW - Blood Vessel Prosthesis

KW - Blood Vessel Prosthesis Implantation

KW - Absorbable Implants

KW - Biological Markers

KW - Matrix Metalloproteinase 9

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DO - 10.1016/j.ejcts.2011.02.077

M3 - Article (Academic Journal)

C2 - 21530291

SN - 1873-734X

VL - 41

SP - 167

EP - 172

JO - European Journal of Cardio-Thoracic Surgery

JF - European Journal of Cardio-Thoracic Surgery

IS - 1

ER -

Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases

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Keywords

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