Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases

Ian Cummings, Sarah George, Jens Kelm, Doerthe Schmidt, Maximilian Y Emmert, Benedikt Weber, Gregor Zünd, Simon P Hoerstrup

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

We have previously demonstrated the functionality and growth of autologous, living, tissue-engineered vascular grafts (TEVGs) in long-term animal studies. These grafts showed substantial in vivo tissue remodeling and approximation to native arterial wall characteristics. Based on this, in vitro and in vivo matrix metalloproteinase (MMP) activity of TEVGs is investigated as a key marker of matrix remodeling.
Original languageEnglish
Pages (from-to)167-72
Number of pages6
JournalEuropean Journal of Cardio-Thoracic Surgery
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Animals
  • Tissue Engineering
  • Matrix Metalloproteinase 2
  • Sheep
  • Tissue Culture Techniques
  • Tissue Scaffolds
  • Disease Models, Animal
  • Collagen
  • Pulmonary Artery
  • Matrix Metalloproteinases
  • Blood Vessel Prosthesis
  • Blood Vessel Prosthesis Implantation
  • Absorbable Implants
  • Biological Markers
  • Matrix Metalloproteinase 9

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