Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

Terje Sjöström; Alistair S. Brydone; R. M. Dominic Meek; Matthew J. Dalby; Bo Su; Laura E. McNamara

doi:10.2217/NNM.12.177

Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

Terje Sjöström, Alistair S. Brydone, R. M. Dominic Meek, Matthew J. Dalby, Bo Su, Laura E. McNamara^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

38 Citations (Scopus)

Abstract

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

Original language	English
Pages (from-to)	89-104
Number of pages	16
Journal	Nanomedicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.2217/NNM.12.177
Publication status	Published - Jan 2013

Keywords

DISORDERED NANOTOPOGRAPHY
TIO2 NANOTUBES
NANOMETER-SCALE
FOCUSED ION-BEAM
nanofabrication
implant
nanotopography
BONE-FORMATION
SURFACE-TOPOGRAPHY
TRANSMISSION ELECTRON-MICROSCOPY
stem cell
dentistry
osteoprogenitor
titanium
bone
osseointegration
HIP-ARTHROPLASTY REGISTER
ADHESION FORMATION
orthopedic
MESENCHYMAL STEM-CELLS

Access to Document

10.2217/NNM.12.177

Handle.net

Persistent link

Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants
Nobbs, A. H. & Su, B.
1/09/13 → 31/12/16
Project: Research
MICRO- AND NANO-PATTERNING OF TITANIUM SURFACES FOR OPTIMAL OSSEOINTERGRATION OF ORTHOPAEDIC IMPLANTS
Su, B.
1/06/09 → 1/06/12
Project: Research

Cite this

@article{898be488fb964c0783b38784ad7e9c0d,

title = "Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices",

abstract = "Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.",

keywords = "DISORDERED NANOTOPOGRAPHY, TIO2 NANOTUBES, NANOMETER-SCALE, FOCUSED ION-BEAM, nanofabrication, implant, nanotopography, BONE-FORMATION, SURFACE-TOPOGRAPHY, TRANSMISSION ELECTRON-MICROSCOPY, stem cell, dentistry, osteoprogenitor, titanium, bone, osseointegration, HIP-ARTHROPLASTY REGISTER, ADHESION FORMATION, orthopedic, MESENCHYMAL STEM-CELLS",

author = "Terje Sj{\"o}str{\"o}m and Brydone, {Alistair S.} and Meek, {R. M. Dominic} and Dalby, {Matthew J.} and Bo Su and McNamara, {Laura E.}",

year = "2013",

month = jan,

doi = "10.2217/NNM.12.177",

language = "English",

volume = "8",

pages = "89--104",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "1",

}

TY - JOUR

T1 - Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

AU - Sjöström, Terje

AU - Brydone, Alistair S.

AU - Meek, R. M. Dominic

AU - Dalby, Matthew J.

AU - Su, Bo

AU - McNamara, Laura E.

PY - 2013/1

Y1 - 2013/1

N2 - Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

AB - Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

KW - DISORDERED NANOTOPOGRAPHY

KW - TIO2 NANOTUBES

KW - NANOMETER-SCALE

KW - FOCUSED ION-BEAM

KW - nanofabrication

KW - implant

KW - nanotopography

KW - BONE-FORMATION

KW - SURFACE-TOPOGRAPHY

KW - TRANSMISSION ELECTRON-MICROSCOPY

KW - stem cell

KW - dentistry

KW - osteoprogenitor

KW - titanium

KW - bone

KW - osseointegration

KW - HIP-ARTHROPLASTY REGISTER

KW - ADHESION FORMATION

KW - orthopedic

KW - MESENCHYMAL STEM-CELLS

U2 - 10.2217/NNM.12.177

DO - 10.2217/NNM.12.177

M3 - Review article (Academic Journal)

SN - 1743-5889

VL - 8

SP - 89

EP - 104

JO - Nanomedicine

JF - Nanomedicine

IS - 1

ER -

Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Projects

Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants

MICRO- AND NANO-PATTERNING OF TITANIUM SURFACES FOR OPTIMAL OSSEOINTERGRATION OF ORTHOPAEDIC IMPLANTS

Cite this