Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

Terje Sjöström, Alistair S. Brydone, R. M. Dominic Meek, Matthew J. Dalby, Bo Su, Laura E. McNamara*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

38 Citations (Scopus)

Abstract

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

Original languageEnglish
Pages (from-to)89-104
Number of pages16
JournalNanomedicine
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • DISORDERED NANOTOPOGRAPHY
  • TIO2 NANOTUBES
  • NANOMETER-SCALE
  • FOCUSED ION-BEAM
  • nanofabrication
  • implant
  • nanotopography
  • BONE-FORMATION
  • SURFACE-TOPOGRAPHY
  • TRANSMISSION ELECTRON-MICROSCOPY
  • stem cell
  • dentistry
  • osteoprogenitor
  • titanium
  • bone
  • osseointegration
  • HIP-ARTHROPLASTY REGISTER
  • ADHESION FORMATION
  • orthopedic
  • MESENCHYMAL STEM-CELLS

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