Total and specific IgE (house dust mite and intestinal helminths) in asthmatics and controls from Gondar, Ethiopia

F G Selassie, R H Stevens, P Cullinan, D Pritchard, M Jones, Jessica M Harris, J G Ayres, A J Newman Taylor

Research output: Contribution to journalArticle (Academic Journal)peer-review

41 Citations (Scopus)

Abstract

BACKGROUND: The role, if any, of parasitosis in the development of asthma remains incompletely understood; both 'protective' and 'predictive' associations have been reported. We report a study which examined immunoglobulin (Ig) E responses to two common helminths in asthmatics living in Ethiopia.

OBJECTIVE: To compare the frequencies of specific IgE antibodies to Ascaris and Necator species and to Der p 1 among 84 adult asthmatics and a referent group of nonasthmatics.

METHODS: A case-control analysis.

RESULTS: Total IgE levels were not different between the two groups. The presence of specific IgE to Der p 1 was strongly associated with asthma (P = 0.001). Raised levels of Ascaris-(P = 0.010) and Necator- (P = 0.001) specific IgE antibodies were more common among referents; there were no associations between specific IgE production to Der p 1 and either of the two parasites.

CONCLUSION: These findings confirm the association between Der p 1 sensitization and asthma among urban, adult Ethiopians. While they also indicate a negative relationship with two indicators of helminth infestation it appears that this is not mediated through the immunological response to common aeroallergens.

Original languageEnglish
Pages (from-to)356-8
Number of pages3
JournalClinical and Experimental Allergy
Volume30
Issue number3
Publication statusPublished - Mar 2000

Keywords

  • Adolescent
  • Adult
  • Allergens
  • Animals
  • Antibodies, Helminth
  • Antigens, Dermatophagoides
  • Ascaris lumbricoides
  • Asthma
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Ethiopia
  • Female
  • Glycoproteins
  • Humans
  • Immunoglobulin E
  • Intestinal Diseases, Parasitic
  • Male
  • Middle Aged
  • Mites
  • Necator americanus

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