Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy

Antonio Jose Grande, Hamish Reid, Emma Thomas, Charlie Foster, Thomas Darton

Research output: Contribution to journalArticle (Academic Journal)

69 Downloads (Pure)

Abstract

Background

Dengue fever is a ubiquitous arboviral infection in tropical and sub-tropical regions, whose incidence has increased over recent decades. In the absence of a rapid point of care test, the clinical diagnosis of dengue is complex. The World Health Organisation has outlined diagnostic criteria for making the diagnosis of dengue infection, which includes the use of the tourniquet test (TT).

Purpose

To assess the quality of the evidence supporting the use of the TT and perform a diagnostic accuracy meta-analysis comparing the TT to antibody response measured by ELISA.

Data Sources

A comprehensive literature search was conducted in the following databases to April, 2016: MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, BIOSIS, Web of Science, SCOPUS.

Study Selection

Studies comparing the diagnostic accuracy of the tourniquet test with ELISA for the diagnosis of dengue were included.

Data Extraction

Two independent authors extracted data using a standardized form.

Data Synthesis

A total of 16 studies with 28,739 participants were included in the meta-analysis. Pooled sensitivity for dengue diagnosis by TT was 58% (95% Confidence Interval (CI), 43%-71%) and the specificity was 71% (95% CI, 60%-80%). In the subgroup analysis sensitivity for non-severe dengue diagnosis was 55% (95% CI, 52%-59%) and the specificity was 63% (95% CI, 60%-66%), whilst sensitivity for dengue hemorrhagic fever diagnosis was 62% (95% CI, 53%-71%) and the specificity was 60% (95% CI, 48%-70%). Receiver-operator characteristics demonstrated a test accuracy (AUC) of 0.70 (95% CI, 0.66–0.74).

Conclusion

The tourniquet test is widely used in resource poor settings despite currently available evidence demonstrating only a marginal benefit in making a diagnosis of dengue infection alone.
Original languageEnglish
Article numbere0004888
Number of pages23
JournalPLoS Neglected Tropical Diseases
Volume10
Issue number8
DOIs
Publication statusPublished - 3 Aug 2016

Fingerprint Dive into the research topics of 'Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy'. Together they form a unique fingerprint.

  • Cite this