Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment

Bethan Lloyd-Lewis, Alexander G Fletcher, Trevor C Dale, Helen M Byrne

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Wnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcriptional co-activator β-catenin. Mathematical and computational models have been used to study the spatial and temporal regulation of the Wnt/β-catenin pathway and to investigate the functional impact of mutations in key components. Such models range in complexity, from time-dependent, ordinary differential equations that describe the biochemical interactions between key pathway components within a single cell, to complex, multiscale models that incorporate the role of the Wnt/β-catenin pathway target genes in tissue homeostasis and carcinogenesis. This review aims to summarize recent progress in mathematical modeling of the Wnt pathway and to highlight new biological results that could form the basis for future theoretical investigations designed to increase the utility of theoretical models of Wnt signaling in the biomedical arena.

Original languageEnglish
Pages (from-to)391-407
Number of pages17
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume5
Issue number4
DOIs
Publication statusPublished - 5 Apr 2013

Bibliographical note

Copyright © 2013 Wiley Periodicals, Inc.

Keywords

  • Cell Communication
  • Cell Cycle
  • Humans
  • Models, Theoretical
  • Wnt Proteins/metabolism
  • Wnt Signaling Pathway
  • beta Catenin/metabolism

Fingerprint Dive into the research topics of 'Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment'. Together they form a unique fingerprint.

Cite this