Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS)

Kristina Hetherington; Som Dutt; Amaurys A Ibarra; Emma E Cawood; Fruzsina Hobor; Derek N Woolfson; Thomas A Edwards; Adam Nelson; Richard B Sessions; Andrew J Wilson

doi:10.1039/d1cb00137j

Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS)

Kristina Hetherington
, Som Dutt
, Amaurys A Ibarra
, Emma E Cawood
, Fruzsina Hobor
, Derek N Woolfson
, Thomas A Edwards
, Adam Nelson
, Richard B Sessions^*
, Andrew J Wilson

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

94 Downloads (Pure)

Abstract

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

Original language	English
Pages (from-to)	1474-1478
Number of pages	5
Journal	RSC Chemical Biology
Volume	2
Issue number	5
DOIs	https://doi.org/10.1039/d1cb00137j
Publication status	Published - 7 Oct 2021

Bibliographical note

Funding Information:
This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1).

Publisher Copyright:
© The Royal Society of Chemistry.

Research Groups and Themes

Bristol BioDesign Institute
Organic & Biological

Keywords

synthetic biology

Access to Document

10.1039/d1cb00137j

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This is the final published version of the article (version of record). It first appeared online via Royal Society of Chemistry at 10.1039/D1CB00137J. Please refer to any applicable terms of use of the publisher.
Final published version, 2.56 MBLicence: CC BY

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Cite this

@article{dcddcbff79d64a578924775763349d1b,

title = "Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS)",

abstract = "A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.",

keywords = "synthetic biology",

author = "Kristina Hetherington and Som Dutt and Ibarra, \{Amaurys A\} and Cawood, \{Emma E\} and Fruzsina Hobor and Woolfson, \{Derek N\} and Edwards, \{Thomas A\} and Adam Nelson and Sessions, \{Richard B\} and Wilson, \{Andrew J\}",

note = "Funding Information: This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = oct,

day = "7",

doi = "10.1039/d1cb00137j",

language = "English",

volume = "2",

pages = "1474--1478",

journal = "RSC Chemical Biology",

issn = "2633-0679",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Towards optimizing peptide-based inhibitors of protein-protein interactions

T2 - predictive saturation variation scanning (PreSaVS)

AU - Hetherington, Kristina

AU - Dutt, Som

AU - Ibarra, Amaurys A

AU - Cawood, Emma E

AU - Hobor, Fruzsina

AU - Woolfson, Derek N

AU - Edwards, Thomas A

AU - Nelson, Adam

AU - Sessions, Richard B

AU - Wilson, Andrew J

N1 - Funding Information: This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/10/7

Y1 - 2021/10/7

N2 - A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

AB - A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

KW - synthetic biology

U2 - 10.1039/d1cb00137j

DO - 10.1039/d1cb00137j

M3 - Article (Academic Journal)

C2 - 34704051

SN - 2633-0679

VL - 2

SP - 1474

EP - 1478

JO - RSC Chemical Biology

JF - RSC Chemical Biology

IS - 5

ER -

Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS)

Abstract

Bibliographical note

Research Groups and Themes

Keywords

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