Abstract
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84–5.29) for men of European ancestry to 3.74 (95% CI, 3.36–4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14–2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71–0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
| Original language | English |
|---|---|
| Pages (from-to) | 65–75 |
| Number of pages | 11 |
| Journal | Nature Genetics |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 4 Jan 2021 |
Bibliographical note
Publisher Copyright:© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature Research at https://doi.org/10.1038/s41588-020-00748-0 . Please refer to any applicable terms of use of the publisher.