Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease

Ashton R M Faulkner*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

The endothelium acts as a gatekeeper, controlling the movement of biomolecules between the circulation and underlying tissues. Although conditions of metabolic stress are traditionally considered as causes of endothelial dysfunction, a principal driver of cardiovascular disease, accumulating evidence suggests that endothelial cells are also active players in maintaining local metabolic homeostasis, in part, through regulating the supply of metabolic substrates, including lipids and glucose, to energy-demanding organs. Therefore, endothelial dysfunction, in terms of altered trans-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within the vascular and metabolism fields that may offer an opportunity for identifying novel therapeutic targets. This mini-review summarises the emerging mechanisms regulating the trafficking of lipids and glucose through the endothelial barrier and how this may impact on the development of cardio-metabolic disease.
Original languageEnglish
Pages (from-to)507-517
Number of pages11
JournalBiochemical Society Transactions
Volume49
Issue number1
Early online date22 Feb 2021
DOIs
Publication statusPublished - 26 Feb 2021

Keywords

  • diabetes
  • endothelial cells
  • fatty acids
  • glucose
  • trafficking
  • transcytosis

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