Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

Iain Dykes, Costanza Emanueli

Research output: Contribution to journalArticle (Academic Journal)peer-review

269 Citations (Scopus)
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Abstract Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.
Original languageEnglish
JournalGenomics, Proteomics & Bioinformatics
Early online date19 May 2017
Publication statusE-pub ahead of print - 19 May 2017


  • Long non-coding RNA
  • MicroRNA
  • Transcriptional regulation
  • Epigenetics
  • Post-transcriptional regulation

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