Transcriptional and post-translational regulation of Arc in synaptic plasticity

Ruth E. Carmichael, Jeremy M. Henley*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

16 Citations (Scopus)
323 Downloads (Pure)

Abstract

One of the most interesting features of Arc-dependent synaptic plasticity is how multiple types of synaptic activity can converge to alter Arc transcription and then diverge to induce different plasticity outcomes, ranging from AMPA receptor internalisation that promotes long-term depression (LTD), to actin stabilisation that promotes long-term potentiation (LTP). This diversity suggests that there must be numerous levels of control to ensure the temporal profile, abundance, localisation and function of Arc are appropriately regulated to effect learning and memory in the correct contexts. The activity-dependent transcription and post-translational modification of Arc are crucial regulators of synaptic plasticity, fine-tuning the function of this key protein depending on the specific situation. The extensive cross-talk between signalling pathways and the numerous routes of Arc regulation provide a complex interplay of processes in which Arc-mediated plasticity can be broadly induced, but specifically tailored to synaptic activity. Here we provide an overview what is currently known about these processes and potential future directions.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume77
Early online date7 Sep 2017
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Arc/Arg3.1
  • Phosphorylation
  • SUMOylation
  • Synaptic plasticity
  • Transcription
  • Ubiquitination

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