Transcriptome analysis of early organogenesis in human embryos

HAI Fang, Y Yang, Chunliang Li, Shijun Fu, Zuqing Yang , Gang Jin, Kankan Wang , Ji Zhang , Ying Jin

Research output: Contribution to journalArticle (Academic Journal)peer-review

55 Citations (Scopus)

Abstract

Genome-wide expression analysis of embryonic development provides information that is useful in a variety of contexts. Here, we report transcriptome profiles of human early embryos covering development during the first third of organogenesis. We identified two major categories of genes, displaying gradually reduced or gradually increased expression patterns across this developmental window. The decreasing group appeared to include stemness-specific and differentiation-specific genes important for the initiation of organogenesis, whereas the increasing group appeared to be largely differentiation related and indicative of diverse organ formation. Based on these findings, we devised a putative molecular network that may provide a framework for the regulation of early human organogenesis. Our results represent a significant step in characterization of early human embryogenesis and provide a resource for understanding human development and for stem cell engineering.
Translated title of the contributionTranscriptome analysis of early organogenesis in human embryos
Original languageEnglish
Pages (from-to)174 - 184
Number of pages11
JournalDevelopmental Cell
Volume19
DOIs
Publication statusPublished - Jul 2010

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