Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

K Plant, KA Pelkey, ZA Bortolotto, D Morita, A Terashima, CJ McBain, GL Collingridge, JTR Isaac

Research output: Contribution to journalArticle (Academic Journal)peer-review

388 Citations (Scopus)

Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approx25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
Translated title of the contributionTransient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Original languageEnglish
Pages (from-to)602 - 604
Number of pages3
JournalNature Neuroscience
Volume9 (5)
DOIs
Publication statusPublished - May 2006

Bibliographical note

Publisher: Nature Publishing Group

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