Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

K Plant; KA Pelkey; ZA Bortolotto; D Morita; A Terashima; CJ McBain; GL Collingridge; JTR Isaac

doi:10.1038/nn1678

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

K Plant, KA Pelkey, ZA Bortolotto, D Morita, A Terashima, CJ McBain, GL Collingridge, JTR Isaac

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approx25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

Translated title of the contribution	Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Original language	English
Pages (from-to)	602 - 604
Number of pages	3
Journal	Nature Neuroscience
Volume	9 (5)
DOIs	https://doi.org/10.1038/nn1678
Publication status	Published - May 2006

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Publisher: Nature Publishing Group

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MECHANISMS OF EXPRESSION OF NMDA RECEPTOR-DEPENDENT LTP AND LTD IN THE HIPPOCAMPUS
Collingridge, G. L. (Principal Investigator)
1/10/06 → 1/01/08
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title = "Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation",

abstract = "Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approx25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.",

author = "K Plant and KA Pelkey and ZA Bortolotto and D Morita and A Terashima and CJ McBain and GL Collingridge and JTR Isaac",

note = "Publisher: Nature Publishing Group",

year = "2006",

month = may,

doi = "10.1038/nn1678",

language = "English",

volume = "9 (5)",

pages = "602 -- 604",

journal = "Nature Neuroscience",

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TY - JOUR

T1 - Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

AU - Plant, K

AU - Pelkey, KA

AU - Bortolotto, ZA

AU - Morita, D

AU - Terashima, A

AU - McBain, CJ

AU - Collingridge, GL

AU - Isaac, JTR

N1 - Publisher: Nature Publishing Group

PY - 2006/5

Y1 - 2006/5

N2 - Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approx25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

AB - Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approx25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

U2 - 10.1038/nn1678

DO - 10.1038/nn1678

M3 - Article (Academic Journal)

SN - 1546-1726

VL - 9 (5)

SP - 602

EP - 604

JO - Nature Neuroscience

JF - Nature Neuroscience

ER -

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

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MECHANISMS OF EXPRESSION OF NMDA RECEPTOR-DEPENDENT LTP AND LTD IN THE HIPPOCAMPUS

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