TY - JOUR
T1 - Translational concepts of mglur5 in synaptic diseases of the brain
AU - Piers, Thomas M.
AU - Kim, Dong Hyun
AU - Kim, Byeong C.
AU - Regan, Philip
AU - Whitcomb, Daniel J.
AU - Cho, Kwangwook
PY - 2012/12/12
Y1 - 2012/12/12
N2 - The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information. Over the last decade, multiple mGluR-related signal cascades have been identified at excitatory synapses, indicating their potential roles in various forms of synaptic function and dysfunction. This review highlights recent studies investigating mGluR5, a subtype of group I mGluRs, and its association with a number of developmental, psychiatric, and senile synaptic disorders with respect to associated synaptic proteins, with an emphasis on translational pre-clinical studies targeting mGluR5 in a range of synaptic diseases of the brain.
AB - The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information. Over the last decade, multiple mGluR-related signal cascades have been identified at excitatory synapses, indicating their potential roles in various forms of synaptic function and dysfunction. This review highlights recent studies investigating mGluR5, a subtype of group I mGluRs, and its association with a number of developmental, psychiatric, and senile synaptic disorders with respect to associated synaptic proteins, with an emphasis on translational pre-clinical studies targeting mGluR5 in a range of synaptic diseases of the brain.
KW - MGluR5
KW - Scaffolding proteins
KW - Synaptic disease
UR - http://www.scopus.com/inward/record.url?scp=84870658352&partnerID=8YFLogxK
U2 - 10.3389/fphar.2012.00199
DO - 10.3389/fphar.2012.00199
M3 - Article (Academic Journal)
C2 - 23205012
AN - SCOPUS:84870658352
SN - 1663-9812
VL - 3
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 199
ER -