Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by type III restriction endonucleases

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13 Citations (Scopus)

Abstract

To cleave DNA, the Type III RM (restriction–modification) enzymes must communicate the relative orientation of two recognition sequences, which may be separated by many thousands of base pairs. This long-range interaction requires ATP hydrolysis by a helicase domain, and both active (DNA translocation) and passive (DNA sliding) modes of motion along DNA have been proposed. Potential roles for ATP binding and hydrolysis by the helicase domains are discussed, with a focus on bipartite ATPases that act as molecular switches.
Translated title of the contributionTranslocation, switching and gating: potential roles for ATP in long-range communication on DNA by type III restriction endonucleases
Original languageEnglish
Pages (from-to)589 - 594
Number of pages6
JournalBiochemical Society Transactions
Volume39 (2)
DOIs
Publication statusPublished - Apr 2011

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