Transporter Proteins in Neurons and Glia

T. S. Otis*, P. D. Dodson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Abstract

Glutamate is the brain's main excitatory neurotransmitter. Upon release, its actions are terminated by a class of proteins called glutamate transporters, which are located on the plasma membranes of neurons and glial cells. Glutamate transporters catalyze the movement of glutamate from the extracellular space to the intracellular space and are able to concentrate glutamate to greater than a millionfold under physiological circumstances by extracting energy from the sodium and potassium ionic gradients. This article discusses what is known about the molecular structure and function, the cellular localization, and the synaptic function of these critical components of excitatory synapses.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherComputational Mechanics Publications/Elsevier Science Publishers Ltd
Pages1159-1166
Number of pages8
ISBN (Print)9780080450469
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • Carrier
  • Clearance
  • Cross-talk
  • Diffusion
  • EAAC1
  • EAAT
  • EAAT4
  • EAAT5
  • GLAST
  • GLT1
  • Ion-coupled
  • Spillover
  • Synapse
  • Transport
  • Uptake

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  • Cite this

    Otis, T. S., & Dodson, P. D. (2010). Transporter Proteins in Neurons and Glia. In Encyclopedia of Neuroscience (pp. 1159-1166). Computational Mechanics Publications/Elsevier Science Publishers Ltd. https://doi.org/10.1016/B978-008045046-9.01211-0