BACKGROUND: Neurological involvement in sarcoidosis is serious and often aggressive. Many patients respond to steroids but some show a progressive course despite treatment with steroids and even more potent immunosuppressive drugs. OBJECTIVE: The aim of this study was to describe our experience in the treatment of refractory neurosarcoidosis with Infliximab--its effect on the course of the disease and side effects. METHODS: A series of four patients are reported with neurosarcoidosis refractory to treatment with steroids combined with various immunosuppressive drugs in whom Infliximab was used. RESULTS: A good response, with improvement or stabilisation of the neurological condition, was seen in all cases, without significant side effects. Infliximab is a chimeric monoclonal antibody that neutralises the biological activity of tumour necrosis factor alpha, a cytokine thought to play an important role in the pathophysiology of sarcoidosis. CONCLUSION: Our experience using Infliximab adds to the growing evidence that it may fulfil a useful role in cases of refractory neurosarcoidosis.
|Translated title of the contribution||Treatment of refractory neurosarcoidosis with Infliximab|
|Pages (from-to)||241 - 246|
|Number of pages||6|
|Journal||Journal of Neurology, Neurosurgery, and Psychiatry|
|Publication status||Published - Mar 2010|