Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer

Grace M Power; Eleanor C M Sanderson; Apostolos Gkatzionis; Tom G Richardson; Kate M Tilling; George Davey Smith; Gibran Hemani

doi:10.1101/2025.09.10.25335479

Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer

Grace M Power^*, Eleanor C M Sanderson, Apostolos Gkatzionis, Tom G Richardson, Kate M Tilling, George Davey Smith, Gibran Hemani

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Original language	English
Number of pages	20
Journal	Journal of Clinical Epidemiology
DOIs	https://doi.org/10.1101/2025.09.10.25335479
Publication status	Submitted - 20 Mar 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1101/2025.09.10.25335479Licence: CC BY

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Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity’s influence on breast cancer risk
Power, G. M., Bhatta, L., Hughes, A. M. M., Medina-Gomez, C., Richmond, A., Leyden, G. M., Lloyd-Lewis, B., Sanderson, E. C. M., Richmond, R., Corfield, E. C., McCartney, D. L., Hayward, C., Marques, I. F., Rivadeneira, F., Åsvold, B. O., Hemani, G., Felix, J. F., Brumpton , B. M., Havdahl, A. & Davey Smith, G., 21 Jan 2026, In: Science Advances. 12, 4, p. 1-17 17 p., eady0374.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Cite this

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title = "Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer",

author = "Power, \{Grace M\} and Sanderson, \{Eleanor C M\} and Apostolos Gkatzionis and Richardson, \{Tom G\} and Tilling, \{Kate M\} and \{Davey Smith\}, George and Gibran Hemani",

year = "2026",

month = mar,

day = "20",

doi = "10.1101/2025.09.10.25335479",

language = "English",

journal = "Journal of Clinical Epidemiology",

issn = "0895-4356",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer

AU - Power, Grace M

AU - Sanderson, Eleanor C M

AU - Gkatzionis, Apostolos

AU - Richardson, Tom G

AU - Tilling, Kate M

AU - Davey Smith, George

AU - Hemani, Gibran

PY - 2026/3/20

Y1 - 2026/3/20

U2 - 10.1101/2025.09.10.25335479

DO - 10.1101/2025.09.10.25335479

M3 - Article (Academic Journal)

SN - 0895-4356

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

ER -

Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer

Abstract

UN SDGs

Access to Document

Handle.net

Research output

Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity’s influence on breast cancer risk

Cite this