Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults

Roshni Joshi, S Goya Wannamethee, Jorgen Engmann, Tom Gaunt, Deborah A Lawlor, Jackie Price, Olia Papacosta, Tina Shah, Therese Tillin, Nishi Chaturvedi, Mika Kivimaki, Diana Kuh, Meena Kumari, Alun D Hughes, Juan P Casas, Steve Humphries, Aroon D Hingorani, A Floriaan Schmidt

Research output: Contribution to journalArticle (Academic Journal)

Abstract

AIMS: Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease; however, there is uncertainty about the role of total triglycerides and the individual triglyceride-containing lipoprotein sub-fractions. We measured 14 triglyceride-containing lipoprotein sub-fractions using nuclear magnetic resonance and examined associations with coronary heart disease and stroke.

METHODS: Triglyceride-containing sub-fraction measures were available in 11,560 participants from the three UK cohorts free of coronary heart disease and stroke at baseline. Multivariable logistic regression was used to estimate the association of each sub-fraction with coronary heart disease and stroke expressed as the odds ratio per standard deviation increment in the corresponding measure.

RESULTS: The 14 triglyceride-containing sub-fractions were positively correlated with one another and with total triglycerides, and inversely correlated with high-density lipoprotein cholesterol (HDL-C). Thirteen sub-fractions were positively associated with coronary heart disease (odds ratio in the range 1.12 to 1.22), with the effect estimates for coronary heart disease being comparable in subgroup analysis of participants with and without type 2 diabetes, and were attenuated after adjustment for HDL-C and LDL-C. There was no evidence for a clear association of any triglyceride lipoprotein sub-fraction with stroke.

CONCLUSIONS: Triglyceride sub-fractions are associated with increased risk of coronary heart disease but not stroke, with attenuation of effects on adjustment for HDL-C and LDL-C.

Original languageEnglish
Pages (from-to)2047487319899621
JournalEuropean Journal of Preventive Cardiology
Early online date29 Jan 2020
DOIs
Publication statusE-pub ahead of print - 29 Jan 2020

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