Trophic regulation of the pituitary

A Levy

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Abstract

A significant proportion of pituitary macroadenomas and by definition all pituitary microadenomas regain trophic stability after an initial period of deregulated growth. Classical proto-oncogene activation and tumor suppressor mutations are rarely responsible and although on-going work continues to unearth mutational hotspots believed to code for novel tumour suppressors, the transience of de-regulated growth remains a mechanistically somewhat paradoxical outcome of their inactivation. This temporary trophic deregulation and other tumour behaviours identified on longer term clinical observations, such as cyclical deregulation in corticotroph adenomas - sometimes with little or no evidence of co-existent trophic abnormalities, and spontaneous resolution of a significant minority of microprolactinomas, suggests that part of the problem might be quantitative rather than qualitative. If this is the case, then a complete understanding of trophic regulation in the normal pituitary is required. The seemingly straightforward task of collecting and collating this data set, still incomplete, is a more complex undertaking than it first appears, as this update will reveal.
Translated title of the contributionTrophic regulation of the pituitary
Original languageEnglish
Title of host publicationBritish Society for Neuroendocrinology meeting, Bristol
Number of pages1
Publication statusPublished - 2008

Bibliographical note

Name and Venue of Event: British Society for Neuroendocrinology meeting, Bristol
Conference Proceedings/Title of Journal: Journal of Neuroendocrinology
Medium/genre: Plenary lecture
Conference Organiser: British Society for Neuroendocrinology

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