Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries

MW Brinkhof, M Egger, A Boulle, M May, E Hosseinipour, E Sprinz, P Braitstein, F Dabis, P Reiss, DR Bangsberg, M Rickenback, JM Miro, L Myer, A Mocroft, D Nash, O Keiser, M Pascoe, S van der Borght, M Schechter

Research output: Contribution to journalArticle (Academic Journal)peer-review

86 Citations (Scopus)

Abstract

We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings
Translated title of the contributionTuberculosis after initiation of antiretroviral therapy in low-income and high-income countries
Original languageEnglish
Pages (from-to)1518 - 1521
Number of pages4
JournalClinical Infectious Diseases
Volume45 (11)
Publication statusPublished - Dec 2007

Bibliographical note

Other identifier: PM:17990236

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