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Tubule occlusion properties of toothpastes: a randomised clinical in-situ study

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Tubule occlusion properties of toothpastes: a randomised clinical in-situ study. / Macdonald, Emma; Seong, Joon; Hellin, Nicola; Jones, Sian; West, Nicola; Creeth, Jon.

2018. Poster session presented at 96th General Session of the IADR, 2018, London, United Kingdom.

Research output: Contribution to conferencePoster

Harvard

Macdonald, E, Seong, J, Hellin, N, Jones, S, West, N & Creeth, J 2018, 'Tubule occlusion properties of toothpastes: a randomised clinical in-situ study', 96th General Session of the IADR, 2018, London, United Kingdom, 25/07/18 - 28/07/18.

APA

Macdonald, E., Seong, J., Hellin, N., Jones, S., West, N., & Creeth, J. (Accepted/In press). Tubule occlusion properties of toothpastes: a randomised clinical in-situ study. Poster session presented at 96th General Session of the IADR, 2018, London, United Kingdom.

Vancouver

Macdonald E, Seong J, Hellin N, Jones S, West N, Creeth J. Tubule occlusion properties of toothpastes: a randomised clinical in-situ study. 2018. Poster session presented at 96th General Session of the IADR, 2018, London, United Kingdom.

Author

Macdonald, Emma ; Seong, Joon ; Hellin, Nicola ; Jones, Sian ; West, Nicola ; Creeth, Jon. / Tubule occlusion properties of toothpastes: a randomised clinical in-situ study. Poster session presented at 96th General Session of the IADR, 2018, London, United Kingdom.

Bibtex

@conference{b493246149734434ab43f0675a7cfbdd,
title = "Tubule occlusion properties of toothpastes: a randomised clinical in-situ study",
abstract = "Objectives: To evaluate the ability of a modified in-situ model to differentiate the dentinal tubule occlusion properties of toothpaste formulations after 1, 4, 8 (primary objective) and 10 days of treatment.Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study in which healthy participants wore two lower oral appliances for 10 days per treatment period. Each appliance held four dentine samples, which were replaced for each treatment period. The samples were power-brushed ex-vivo twice on each treatment day with a test toothpaste containing 0.454{\%} stannous fluoride, a conventional fluoride toothpaste containing 0.76{\%} sodium monofluorophosphate or water. Dentine samples were subjected to in-situ acid challenge (orange juice) on Days 9 and 10. On days 1, 4, 8 and 10, one sample was removed from each appliance and imaged using scanning electron microscopy. Images were graded for occlusion (0–5) by four calibrated examiners. Change from baseline in mean occlusion classification score was calculated using Mixed Model Repeated Measures analysis.Results: Twenty-one of 24 participants randomised to study treatments completed all three treatment periods. After 4 days’ treatment, the degree of tubule occlusion statistically significantly increased for the samples treated with the test (p=0.0023) or conventional (p=0.0194) toothpastes compared with the water-treated samples. Following the acid challenge (Day 10), there was a statistically significantly greater degree of occlusion in the test toothpaste treated samples compared with those treated with water (p=0.0058). No other between-treatment differences, including at day 8, were statistically significant. Study treatments were generally well tolerated.Conclusions: In this study, the modified in-situ model did not demonstrate statistically significant differences between toothpastes in dentinal tubule occlusion. The model requires further development to improve differentiation between products.",
author = "Emma Macdonald and Joon Seong and Nicola Hellin and Sian Jones and Nicola West and Jon Creeth",
year = "2018",
month = "4",
day = "4",
language = "English",
note = "96th General Session of the IADR, 2018 ; Conference date: 25-07-2018 Through 28-07-2018",
url = "http://www.iadr.org/IADR/Meetings/2018IAGS",

}

RIS - suitable for import to EndNote

TY - CONF

T1 - Tubule occlusion properties of toothpastes: a randomised clinical in-situ study

AU - Macdonald, Emma

AU - Seong, Joon

AU - Hellin, Nicola

AU - Jones, Sian

AU - West, Nicola

AU - Creeth, Jon

PY - 2018/4/4

Y1 - 2018/4/4

N2 - Objectives: To evaluate the ability of a modified in-situ model to differentiate the dentinal tubule occlusion properties of toothpaste formulations after 1, 4, 8 (primary objective) and 10 days of treatment.Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study in which healthy participants wore two lower oral appliances for 10 days per treatment period. Each appliance held four dentine samples, which were replaced for each treatment period. The samples were power-brushed ex-vivo twice on each treatment day with a test toothpaste containing 0.454% stannous fluoride, a conventional fluoride toothpaste containing 0.76% sodium monofluorophosphate or water. Dentine samples were subjected to in-situ acid challenge (orange juice) on Days 9 and 10. On days 1, 4, 8 and 10, one sample was removed from each appliance and imaged using scanning electron microscopy. Images were graded for occlusion (0–5) by four calibrated examiners. Change from baseline in mean occlusion classification score was calculated using Mixed Model Repeated Measures analysis.Results: Twenty-one of 24 participants randomised to study treatments completed all three treatment periods. After 4 days’ treatment, the degree of tubule occlusion statistically significantly increased for the samples treated with the test (p=0.0023) or conventional (p=0.0194) toothpastes compared with the water-treated samples. Following the acid challenge (Day 10), there was a statistically significantly greater degree of occlusion in the test toothpaste treated samples compared with those treated with water (p=0.0058). No other between-treatment differences, including at day 8, were statistically significant. Study treatments were generally well tolerated.Conclusions: In this study, the modified in-situ model did not demonstrate statistically significant differences between toothpastes in dentinal tubule occlusion. The model requires further development to improve differentiation between products.

AB - Objectives: To evaluate the ability of a modified in-situ model to differentiate the dentinal tubule occlusion properties of toothpaste formulations after 1, 4, 8 (primary objective) and 10 days of treatment.Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study in which healthy participants wore two lower oral appliances for 10 days per treatment period. Each appliance held four dentine samples, which were replaced for each treatment period. The samples were power-brushed ex-vivo twice on each treatment day with a test toothpaste containing 0.454% stannous fluoride, a conventional fluoride toothpaste containing 0.76% sodium monofluorophosphate or water. Dentine samples were subjected to in-situ acid challenge (orange juice) on Days 9 and 10. On days 1, 4, 8 and 10, one sample was removed from each appliance and imaged using scanning electron microscopy. Images were graded for occlusion (0–5) by four calibrated examiners. Change from baseline in mean occlusion classification score was calculated using Mixed Model Repeated Measures analysis.Results: Twenty-one of 24 participants randomised to study treatments completed all three treatment periods. After 4 days’ treatment, the degree of tubule occlusion statistically significantly increased for the samples treated with the test (p=0.0023) or conventional (p=0.0194) toothpastes compared with the water-treated samples. Following the acid challenge (Day 10), there was a statistically significantly greater degree of occlusion in the test toothpaste treated samples compared with those treated with water (p=0.0058). No other between-treatment differences, including at day 8, were statistically significant. Study treatments were generally well tolerated.Conclusions: In this study, the modified in-situ model did not demonstrate statistically significant differences between toothpastes in dentinal tubule occlusion. The model requires further development to improve differentiation between products.

M3 - Poster

ER -