We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.
Bibliographical note© 2012 Blackwell Publishing Ltd.
- Gene Frequency
- Genetic Predisposition to Disease
- Middle Aged
- Minisatellite Repeats
- Osteoarthritis, Knee
- Polymorphism, Single Nucleotide
- Sex Factors