Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

S L Hulin-Curtis, J L Bidwell, M J Perry

Research output: Contribution to journalArticle (Academic Journal)

Abstract

We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.
Original languageEnglish
Pages (from-to)207-9
Number of pages3
JournalInternational Journal of Immunogenetics
Volume39
Issue number3
DOIs
Publication statusPublished - Jun 2012

Bibliographical note

© 2012 Blackwell Publishing Ltd.

Keywords

  • Alleles
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Minisatellite Repeats
  • Osteoarthritis, Knee
  • Osteoprotegerin
  • Polymorphism, Single Nucleotide
  • Sex Factors

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