Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

S L Hulin-Curtis; J L Bidwell; M J Perry

doi:10.1111/j.1744-313X.2012.01083.x

Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

S L Hulin-Curtis, J L Bidwell, M J Perry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.

Original language	English
Pages (from-to)	207-9
Number of pages	3
Journal	International Journal of Immunogenetics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1111/j.1744-313X.2012.01083.x
Publication status	Published - Jun 2012

Bibliographical note

Keywords

Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Minisatellite Repeats
Osteoarthritis, Knee
Osteoprotegerin
Polymorphism, Single Nucleotide
Sex Factors

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@article{448ed55171a44bfcbc71e0a827b35b0f,

title = "Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women",

abstract = "We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.",

keywords = "Alleles, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Minisatellite Repeats, Osteoarthritis, Knee, Osteoprotegerin, Polymorphism, Single Nucleotide, Sex Factors",

author = "Hulin-Curtis, {S L} and Bidwell, {J L} and Perry, {M J}",

note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",

year = "2012",

month = jun,

doi = "10.1111/j.1744-313X.2012.01083.x",

language = "English",

volume = "39",

pages = "207--9",

journal = "International Journal of Immunogenetics",

issn = "1744-3121",

publisher = "Wiley",

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}

TY - JOUR

T1 - Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

AU - Hulin-Curtis, S L

AU - Bidwell, J L

AU - Perry, M J

PY - 2012/6

Y1 - 2012/6

N2 - We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.

AB - We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.

KW - Alleles

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Minisatellite Repeats

KW - Osteoarthritis, Knee

KW - Osteoprotegerin

KW - Polymorphism, Single Nucleotide

KW - Sex Factors

U2 - 10.1111/j.1744-313X.2012.01083.x

DO - 10.1111/j.1744-313X.2012.01083.x

M3 - Article (Academic Journal)

C2 - 22296645

SN - 1744-3121

VL - 39

SP - 207

EP - 209

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 3

ER -

Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

Abstract

Bibliographical note

Keywords

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