Two chaperonin systems in bacterial genomes with distinct ecological roles

Tom A. Williams*, Francisco M. Codoñer, Christina Toft, Mario A. Fares

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)

Abstract

Bacterial chaperonins are essential to cell viability and have a role in endosymbiosis, which leads to increased biological complexity. However, the extent to which chaperonins promote ecological innovation is unknown. We screened 622 bacterial genomes for genes encoding chaperonins, and found archaeal-like chaperonins in bacteria that inhabit archaeal ecological niches. We found that chaperonins encoded in pathogenic bacteria are the most functionally divergent. We identified the molecular basis of the dramatic structural changes in mitochondrial GROEL, a highly derived chaperonin gene. Our analysis suggests that chaperonins are important capacitors of evolutionary and ecological change.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalTrends in genetics
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 2010

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