Two-colour screening in combinatorial chemistry: prospecting for enantioselectivity in a library of steroid-based receptors

Vicente del Amo, Adam P. McGlone, Jose M. Soriano, Anthony P. Davis

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)


The screening of resin-bound combinatorial libraries with pairs of dye-tagged substrates is a powerful strategy for discovering selective receptors. However, implementation has been hampered by a lack of complementary but chemically similar dyes. We now show that the well-established Disperse Red 1 and the recently-introduced Bristol Blue 1 can be used in parallel to synthesise 'pseudoenantiomeric' analogues of N-acetyl-alpha-amino acids and of the anti-inflammatory drug Naproxen. A steroid-based receptor library has been prepared and screened with these substrates. Preliminary results suggest that some members may be highly enantioselective receptors for N-acetyl-alpha-amino acids. (C) 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6370-6381
Number of pages12
Issue number32
Publication statusPublished - 8 Aug 2009

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