Two mechanisms drive pronuclear migration in mouse zygotes

et al.

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)
108 Downloads (Pure)


A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei near the surface of the fertilized egg. The mechanisms that then move the pronuclei inwards for their unification are only poorly understood in mammals. Here, we report two mechanisms that act in concert to unite the parental genomes in fertilized mouse eggs. The male pronucleus assembles within the fertilization cone and is rapidly moved inwards by the flattening cone. Rab11a recruits the actin nucleation factors Spire and Formin-2 into the fertilization cone, where they locally nucleate actin and further accelerate the pronucleus inwards. In parallel, a dynamic network of microtubules assembles that slowly moves the male and female pronuclei towards the cell centre in a dynein-dependent manner. Both mechanisms are partially redundant and act in concert to unite the parental pronuclei in the zygote’s centre.
Original languageEnglish
Article number841 (2021)
Number of pages18
JournalNature Communications
Issue number1
Publication statusPublished - 5 Feb 2021


Dive into the research topics of 'Two mechanisms drive pronuclear migration in mouse zygotes'. Together they form a unique fingerprint.

Cite this