Type 1 Diabetes: Current Perspectives

Aizhan Kozhakhmetova; Kathleen M Gillespie

doi:10.1007/7651_2015_289

Type 1 Diabetes: Current Perspectives

Aizhan Kozhakhmetova, Kathleen M Gillespie

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

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Abstract

Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic susceptibility factors are decreasing in frequency as the incidence of the condition increases. This suggests a growing role for environmental determinants but these have been difficult to identify and our understanding of gene/environment effects are limited. Individuals "at risk" can be identified accurately through the presence of multiple islet autoantibodies and current efforts in type 1 diabetes research focus on improved biomarkers and strategies to prevent or reverse the condition through immunotherapy.

Original language	English
Title of host publication	Type 1 Diabetes
Editors	Kathleen Gillespie
Place of Publication	Humana Press
Publisher	Springer
Pages	1-9
Number of pages	11
ISBN (Electronic)	ISBN 978-1-4939-3643-4
DOIs	https://doi.org/10.1007/7651_2015_289
Publication status	Published - 13 Dec 2015

Publication series

Name	Methods in Molecular Biology
Publisher	Springer
Volume	1433

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Type 1 Diabetes: Current Perspectives

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