Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

The Karolinska KI/K COVID-19 Study Group; Benedikt Strunz; Christopher Maucourant; Adi Mehta; Hui Wan; Likun Du; Dan Sun; Puran Chen; Anna Nordlander; Yu Gao; Martin Cornillet; Jonna Bister; Egle Kvedaraite; Wanda Christ; Jonas Klingström; Daniel Geanon; Åsa Parke; Anna Ekwall-Larson; Laura Rivino; Paul A MacAry; Soo Aleman; Marcus Buggert; Hans-Gustaf Ljunggren; Qiang Pan-Hammarström; Fridtjof Lund-Johansen; Kristoffer Strålin; Niklas K Björkström

doi:10.1093/infdis/jiae036

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

The Karolinska KI/K COVID-19 Study Group
, Benedikt Strunz
, Christopher Maucourant
, Adi Mehta
, Hui Wan
, Likun Du
, Dan Sun
, Puran Chen
, Anna Nordlander
, Yu Gao
, Martin Cornillet
, Jonna Bister
, Egle Kvedaraite
, Wanda Christ
, Jonas Klingström
, Daniel Geanon
, Åsa Parke
, Anna Ekwall-Larson
, Laura Rivino
, Paul A MacAry

Soo Aleman, Marcus Buggert, Hans-Gustaf Ljunggren, Qiang Pan-Hammarström, Fridtjof Lund-Johansen, Kristoffer Strålin, Niklas K Björkström^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

5 Citations (Scopus)

Abstract

Background:
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).

Methods:
This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.

Results:
aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.

Conclusions:
Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

Original language	English
Article number	jiae036
Pages (from-to)	e318-e326
Number of pages	10
Journal	The Journal of infectious diseases
Volume	230
Issue number	2
Early online date	29 Feb 2024
DOIs	https://doi.org/10.1093/infdis/jiae036
Publication status	Published - 15 Aug 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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The Karolinska KI/K COVID-19 Study Group, Strunz, B., Maucourant, C., Mehta, A., Wan, H., Du, L., Sun, D., Chen, P., Nordlander, A., Gao, Y., Cornillet, M., Bister, J., Kvedaraite, E., Christ, W., Klingström, J., Geanon, D., Parke, Å., Ekwall-Larson, A., Rivino, L., ... Björkström, N. K. (2024). Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19. The Journal of infectious diseases, 230(2), e318-e326. Article jiae036. https://doi.org/10.1093/infdis/jiae036

@article{f7fb6b4c19a94f9db33405148455b678,

title = "Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19",

abstract = "Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods: This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results: aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions: Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.",

author = "\{The Karolinska KI/K COVID-19 Study Group\} and Benedikt Strunz and Christopher Maucourant and Adi Mehta and Hui Wan and Likun Du and Dan Sun and Puran Chen and Anna Nordlander and Yu Gao and Martin Cornillet and Jonna Bister and Egle Kvedaraite and Wanda Christ and Jonas Klingstr{\"o}m and Daniel Geanon and {\AA}sa Parke and Anna Ekwall-Larson and Laura Rivino and MacAry, \{Paul A\} and Soo Aleman and Marcus Buggert and Hans-Gustaf Ljunggren and Qiang Pan-Hammarstr{\"o}m and Fridtjof Lund-Johansen and Kristoffer Str{\aa}lin and Bj{\"o}rkstr{\"o}m, \{Niklas K\} and Hedvig Glans and Pontus Naucl{\'e}r and Olav Rooyackers and Johan M{\aa}rtensson",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2024",

month = aug,

day = "15",

doi = "10.1093/infdis/jiae036",

language = "English",

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The Karolinska KI/K COVID-19 Study Group, Strunz, B, Maucourant, C, Mehta, A, Wan, H, Du, L, Sun, D, Chen, P, Nordlander, A, Gao, Y, Cornillet, M, Bister, J, Kvedaraite, E, Christ, W, Klingström, J, Geanon, D, Parke, Å, Ekwall-Larson, A, Rivino, L, MacAry, PA, Aleman, S, Buggert, M, Ljunggren, H-G, Pan-Hammarström, Q, Lund-Johansen, F, Strålin, K & Björkström, NK 2024, 'Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19', The Journal of infectious diseases, vol. 230, no. 2, jiae036, pp. e318-e326. https://doi.org/10.1093/infdis/jiae036

TY - JOUR

T1 - Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

AU - The Karolinska KI/K COVID-19 Study Group

AU - Strunz, Benedikt

AU - Maucourant, Christopher

AU - Mehta, Adi

AU - Wan, Hui

AU - Du, Likun

AU - Sun, Dan

AU - Chen, Puran

AU - Nordlander, Anna

AU - Gao, Yu

AU - Cornillet, Martin

AU - Bister, Jonna

AU - Kvedaraite, Egle

AU - Christ, Wanda

AU - Klingström, Jonas

AU - Geanon, Daniel

AU - Parke, Åsa

AU - Ekwall-Larson, Anna

AU - Rivino, Laura

AU - MacAry, Paul A

AU - Aleman, Soo

AU - Buggert, Marcus

AU - Ljunggren, Hans-Gustaf

AU - Pan-Hammarström, Qiang

AU - Lund-Johansen, Fridtjof

AU - Strålin, Kristoffer

AU - Björkström, Niklas K

AU - Glans, Hedvig

AU - Nauclér, Pontus

AU - Rooyackers, Olav

AU - Mårtensson, Johan

PY - 2024/8/15

Y1 - 2024/8/15

N2 - Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods: This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results: aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions: Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

AB - Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods: This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results: aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions: Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

U2 - 10.1093/infdis/jiae036

DO - 10.1093/infdis/jiae036

M3 - Article (Academic Journal)

C2 - 38421006

SN - 0022-1899

VL - 230

SP - e318-e326

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 2

M1 - jiae036

ER -

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

Abstract

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