Abstract
Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the viral genome, and to replicate progeny whilst diverting cellular immunity. The role of ubiquitin is to regulate fundamental cellular processes such as endocytosis, protein degradation, and immune signaling. Many viruses including influenza A virus (IAV) usurp ubiquitination and ubiquitin-like modifications to establish infection. In this focused review, we discuss how ubiquitin and unanchored ubiquitin regulate IAV host cell entry, and how histone deacetylase 6 (HDAC6), a cytoplasmic deacetylase with ubiquitin-binding activity, mediates IAV capsid uncoating. We also discuss the roles of ubiquitin in innate immunity and its implications in the IAV life cycle.
| Original language | English |
|---|---|
| Article number | 293 |
| Number of pages | 15 |
| Journal | Viruses |
| Volume | 8 |
| Issue number | 10 |
| Early online date | 24 Oct 2016 |
| DOIs | |
| Publication status | Published - Oct 2016 |
Keywords
- ubiquitin
- unanchored ubiquitin
- HDAC6
- aggresome processing
- influenza virus
- virus entry
- virus uncoating
- innate immunity
- virus–host interactions
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Cite this
Rudnicka, A., & Yamauchi, Y. (2016). Ubiquitin in Influenza Virus Entry and Innate Immunity. Viruses, 8(10), [293]. https://doi.org/10.3390/v8100293