Ubiquitin in Influenza Virus Entry and Innate Immunity

Alina Rudnicka, Yohei Yamauchi

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)
330 Downloads (Pure)

Abstract

Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the viral genome, and to replicate progeny whilst diverting cellular immunity. The role of ubiquitin is to regulate fundamental cellular processes such as endocytosis, protein degradation, and immune signaling. Many viruses including influenza A virus (IAV) usurp ubiquitination and ubiquitin-like modifications to establish infection. In this focused review, we discuss how ubiquitin and unanchored ubiquitin regulate IAV host cell entry, and how histone deacetylase 6 (HDAC6), a cytoplasmic deacetylase with ubiquitin-binding activity, mediates IAV capsid uncoating. We also discuss the roles of ubiquitin in innate immunity and its implications in the IAV life cycle.
Original languageEnglish
Article number293
Number of pages15
JournalViruses
Volume8
Issue number10
Early online date24 Oct 2016
DOIs
Publication statusPublished - Oct 2016

Keywords

  • ubiquitin
  • unanchored ubiquitin
  • HDAC6
  • aggresome processing
  • influenza virus
  • virus entry
  • virus uncoating
  • innate immunity
  • virus–host interactions

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